Recurrent Pregnancy Loss

Recurrent pregnancy loss is a common occurrence, which can be defined as the condition in which 3 consecutive pregnancy loss before 20 weeks from the last menstrual period. Recurrent pregnancy loss can physically and emotionally tax for a couple. The condition can be referred to as a recurrent miscarriage or habitual abortion. There are a small number of accepted etiology for recurrent pregnancy loss. It includes untreated hypothyroidism, uncontrolled diabetes mellitus, parental chromosomal abnormalities, certain uterine anatomical abnormalities, and antiphospholipid antibody syndrome. Other possible etiologies include additional endocrine disorder, heritable or acquired thrombophilias, infections, and environmental factors.
 
Recurrent pregnancy loss is one of the most unfortunate episodes that deprive you of getting the taste of parenthood. This is a burning issue that can be well-treated with utmost care and precaution. Urvaraa IVF is one of the sophisticated platforms that can effectively manage and treat this unfortunate situation. The reputed and celebrated physicians of the institution are devoted and highly committed to our dear patients. We can offer you the best treatment to prevent and manage recurrent pregnancy losses so that you can relish the taste of parenthood within the deserving period. We secure the top niche for recurrent miscarriage management in Kolkata, India.
 
Causes

  • Genetic etiologies:

Structural abnormalities associated with recurrent pregnancy loss are chromosomal inversions, insertions, and mosaicism, single gene defects such as those associated with sickle cell anemia or cystic fibrosis, etc.

  • Anatomical etiologies:

Anatomical reasons that result in recurrent miscarriage are thought to cause by interrupting the vasculature of the endometrium, prompting abnormal and inadequate placentation. The causes that interrupt the vasculature may be congenital uterine abnormalities, intrauterine adhesions, and uterine fibroids or polyps. The uterine septum is the congenital abnormality of the uterus that has a close link with recurrent pregnancy loss. Intramural fibroids and submucosal fibroids can cause pregnancy loss. Diagnostic evaluation of uterine anatomical abnormalities can be identified by hysteroscopy or hysterosalpingography. Myomectomy can be considered in cases of submucosal fibroids.

  • Endocrine etiologies

Endocrinologic disorders which may implicate recurrent pregnancy loss are luteal phase defect, polycystic ovarian syndrome, thyroid disease, diabetes mellitus, hyperprolactinemia.
 
 – Luteal phase defect may occur due to inadequate production of progesterone and insufficient endometrial maturation for implantation. Insulin resistant and resultant hyperinsulinemia which are present in PCOS can result in recurrent miscarriage.

 – Poorly controlled diabetes mellitus and uncontrolled hypothyroidism are associated with miscarriages.

 – Evaluation of endocrine disorder is based on the patient’s presentation include insulin resistance test, ovarian reserve testing, serum prolactin in the presence of irregular menses.

  • Infectious etiologies

Some infections include Listeria monocytogenes, Toxoplasma gondii, herpes simplex, rubella, measles are suspected to cause recurrent pregnancy loss.

  • Immunological etiologies

Immunological disorders may cause RPL.

  • Thrombotic etiologies

Both inherited and acquired Thrombophiliasis can be a reason for recurrent pregnancy loss.

 

Treatment
 
If you are suffered from more than 2 miscarriages, then you have to talk to your doctor for his suggestions. Sometimes you have to take some measures to correct the issue behind the condition.

  • Surgery

If some extra tissues separate the uterus like septum, uterine fibroids, or scar tissue, then surgery is suggested. Correction of the shape of the uterus may help in resolving the issue.

  • Blood-thinning medicines

Patient with thrombophilia can be treated with low dose aspirin or heparin. It can reduce the risk of miscarriage.

  • Correcting other medical problems

If there is an abnormal blood sugar level, over/ underactive thyroid gland or high level of prolactin, then they have to be treated to avoid the risk of abortions.

  • Genetic screening

The parent’s blood can be studied to know if there is any translocation. If there is some problem then the doctor will recommend genetic counseling.

 

FAQs
 

  1. Is recurrent miscarriage considered infertility?

Recurrent abortions sometimes considered as infertility. But if the cause is manageable, there will be chances for pregnancy.
 

  1. Is progesterone an effective treatment in unexplained recurrent pregnancy loss?

Progesterone is a female sex hormone which causes secretory changes in the uterine lining. It helps in successful implantation. So it can be considered as a probable solution for spontaneous miscarriages.
 

  1. How soon after a pregnancy loss, a woman can try for another pregnancy?

Recent studies show that there is an increased chance for pregnancy shortly after pregnancy loss. Some other studies found that pregnancy after 3 months of pregnancy loss is more likely to become pregnant and to have a live birth.
 

  1. If a woman loses a pregnancy, is she at higher risk of another abortion?

Pregnancy loss is onetime occurrence mostly. However, if there is loss of a pregnancy, the chance for the next pregnancy to end up in abortion is high. Recurrent pregnancy loss must have an underlying cause, unlike other types of pregnancy loss. If the condition is treated, which improve the chance of another pregnancy.
 

  1. What is spotting during pregnancy, and does symbolize a pregnancy loss?

Many pregnant woman experience spotting/light bleeding on the first trimester and some in their second and third trimester. It is considered as normal. When there is heavy bleeding through the vagina, then you can suspect for an issue, most probably a pregnancy loss.

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